Data
Official data in SubjectManager for the following academic year: 2023-2024
Course director
-
Dr. Balázs DEBRECENI
associate professor,
Department of Biochemistry and Medical Chemistry -
Number of hours/semester
lectures: 42 hours
practices: 0 hours
seminars: 14 hours
total of: 56 hours
Subject data
- Code of subject: OSA-BKZ-T
- 4 kredit
- Dentistry
- Basic modul
- autumn
OSA-OKF-T completed , OSA-BEF-T completed
Exam course:yes
Course headcount limitations
min. 5 – max. 200
Topic
The subject gives an overview of the molecular processes occurring in living organisms from two major aspects. On the one hand, following the subject -Introduction to Biochemistry, it describes the metabolism of the four major types of biomolecules (carbohydrates, lipids, amino ac ids/proteins and nucleotides /nucleic acids) along with the indirect enzymatic regulation of
these processes. On the other hand, built on the subject -Molecular Cell Biology, accounts for the molecular processes responsible for the transmission of information within the living organisms from molecular biological (DNA-RNA-protein-metabolite) as well as hormonal point of view. The subject lies down the foundations of the subjects Pharmacology and Clinical Chemistry.
Lectures
- 1. Introduction - Dr. Debreceni Balázs
- 2. Biochemical processes (overview) - Dr. Veres Balázs
- 3. Reactions of glycolysis - Dr. Veres Balázs
- 4. Regulation of glycolysis - Dr. Veres Balázs
- 5. Metabolic pathways linked to glycolysis - Dr. Veres Balázs
- 6. Pentose phosphate pathway - Dr. Veres Balázs
- 7. Reactions of TCA cycle (PDC included) - Dr. Veres Balázs
- 8. Regulation of TCA cycle - Dr. Veres Balázs
- 9. Fatty acid oxidation - Dr. Jávor-Hocsák Enikő
- 10. Ketonbodies - Dr. Jávor-Hocsák Enikő
- 11. Respiratory chain and its inhibition - Dr. Takátsy Anikó
- 12. ATP synthesis - Dr. Takátsy Anikó
- 13. Mitochondrial transport processes, shuttles - Dr. Takátsy Anikó
- 14. Gluconeogenesis - Dr. Takátsy Anikó
- 15. Glycogen synthesis and degradation - Dr. Berente Zoltán
- 16. Regulation of glycogen metabolism - Dr. Gallyas Ferenc
- 17. Regulation of carbohydrate metabolism - Dr. Gallyas Ferenc
- 18. Fatty acid synthesis - Dr. Gallyas Ferenc
- 19. Synthesis of complex lipids - Dr. Balogi Zsolt
- 20. Cholesterol and lipoproteins - Dr. Balogi Zsolt
- 21. Regulation of lipid metabolism - Dr. Tapodi Antal
- 22. Amino acid metabolism: the fate of amino group - Dr. Tapodi Antal
- 23. Urea cycle - Dr. Tapodi Antal
- 24. Amino acid metabolism: the fate of carbon skeleton - Dr. Kovács Krisztina
- 25. Synthesis of non-essential amino acids - Dr. Kovács Krisztina
- 26. Enzymopathies in amino acid metabolism - Dr. Kovács Krisztina
- 27. Biologically active compounds - Dr. Kovács Krisztina
- 28. Synthesis of purin and pyrimidin nucleotides - Dr. Bognár Zita
- 29. Degradation of purin and pyrimidin nucleotides - Dr. Bognár Zita
- 30. Protein -DNA interactions - Nagyné Dr. Kiss Gyöngyi
- 31. Regulation of gene expression - Nagyné Dr. Kiss Gyöngyi
- 32. Small RNAs - Nagyné Dr. Kiss Gyöngyi
- 33. Retroviruses - Dr. Tapodi Antal
- 34. Folding, PTM - Dr. Tapodi Antal
- 35. Protein targeting, degradation - Dr. Berente Zoltán
- 36. Hormones 1 - Dr. Bognár Zita
- 37. Hormones 2 - Dr. Bognár Zita
- 38. Signal transduction I. - Dr. Gallyas Ferenc
- 39. Signal transduction II. - Dr. Gallyas Ferenc
- 40. Signal transduction III. - Dr. Gallyas Ferenc
- 41. Water soluble vitamins - Dr. Jávor-Hocsák Enikő
- 42. Fat soluble vitamins - Dr. Jávor-Hocsák Enikő
Practices
Seminars
- 1. Carbohydrate metabolism
- 2. Carbohydrate metabolism
- 3. Lipids - metabolism
- 4. Lipids - metabolism
- 5. Respiratory chain
- 6. ATP calculation
- 7. Amino acid metabolism
- 8. Amino acid metabolism
- 9. Purine and pyrimidine nucleotides
- 10. Purine and pyrimidine nucleotides
- 11. Student demonstrations
- 12. Student demonstrations
- 13. Consultation
- 14. consultation
Reading material
Obligatory literature
Nelson, Cox: Lehninger Principles of Biochemistry, 6th edition, W.H. Freeman, 2013
Literature developed by the Department
www.aok.pte.hu
Notes
www.aok.pte.hu
Recommended literature
Berg, Tymoczko, Stryer: Biochemistry, 7th edition, W.H. Freeman, 2012.
Devlin: Textbook of Biochemistry with Clinical Correlations 7th edition, Wiley, 2010.
Conditions for acceptance of the semester
Maximum of 15 % absence allowed
Mid-term exams
It is obligatory to visit the lectures. There are seminars at every EVEN NUMBERED EDUCATIONAL weeks (2-4-6-8-10-12-14). There are short tests from week 4 till 14. The lab is beginning with a short test (time is 6 minutes; 6 occasions; max. 6 exampoints). These points cannot be added to the minimum questions, but they will be added to the final score. Requirement for acceptance is writing 5 test out of 6 possibility.
There is no possibilities to write a short test if delaying is over 5 minutes. No more than 10 minutes delay is accepted, over of it, it is an absence. No more than 1 absence is allowed from the 7 seminars(15%).
Making up for missed classes
Non
Exam topics/questions
The exam is based on the topic of the lectures and labs. Writen exam, 7 MRT question. The exam conditions are on the website of the department. (http://aok.pte.hu/en/egyseg/oktatasianyagok/20)
Examiners
- Dr. Bognár Zita
- Dr. Debreceni Balázs
Instructor / tutor of practices and seminars
- Dr. Bognár Zita
- Dr. Debreceni Balázs